Nota Biográfica
Eu sou professor na Escola Superior de Saúde do Instituto Politécnico do Porto. Licenciei-me em Química em 2002 e recebi o meu mestrado em 2006 na Faculdade de Ciências da Universidade do Porto. Eu trabalhei sob a supervisão de Paula Gomes dedicada ao estudo estereoquímico da ciclização de imidazolidin-4-ona em derivados de primaquina.
Concluí em 2013 o doutoramento em Química Sustentável na Faculdade de Ciências e Tecnologia da Universidade Nova de Lisboa sob a supervisão de Cristina Prudêncio, João Paulo Noronha e Zeljko Petrovski. O trabalho intitulava-se "Development of Novel Active Pharmaceutical Ionic Liquids and Salts Based on Antibiotics and Anti-fungal Drugs".
Neste momento a minha linha de investigação é Nova Abordagem Terapêutica Baseada em Líquidos Iónicos:
- Síntese e caracterização físico-química de líquidos iónicos
- API-ILs: líquidos iónicos derivados de ingredientes farmacêuticos ativos
Interesses de Investigação
Síntese peptídica; Desenvolvimento de novos medicamentos; Análise estrutural de moléculas orgânicas; Resistência a antibióticos; Aplicações terapêuticas de líquidos iónicos.
Web of Science Researcher ID G-5639-2011
Orcid ID 0000-0002-1761-117X
Ciência ID 001E-71CE-F92D
Scopus Author ID 24464208500
Gabinete 1.01.02
Correio Eletrónico
Publicações Principais
"Clicking" an ionic liquid to a potent antimicrobial peptide: on the route towards improved stability International Journal of Molecular Sciences, 21:6174 (2020)
Gomes, A. Bessa, L. J.; Correia, P.; Fernandes, I.; Ferraz, R.; Gameiro, P.; Teixeira, C.; Gomes, P.
Published in a journal of Q1 in the field of Biochemistry and Molecular Biology. In this work I was responsible for the new methodology of coupling ILs to peptides. This is in framework of my PhD Student, Ana Gomes (Doctoral Grant PD/BD/135073/2017)
Building on Surface-Active Ionic Liquids for the Rescuing of the Antimalarial Drug Chloroquine
International Journal of Molecular Sciences, 21:5334 (2020)
Silva, A. T.; Lobo, L.; Oliveira, I. S. Gomes, J. Teixeira, C.; Nogueira, F.; Marques, E. F.; Ferraz, R.; Gomes, P.
Published in a journal of Q1 in the field of Biochemistry and Molecular Biology. In this work I was responsible for the synthetic methodology to produce new Surfactant Active Ionic Liquids.
This is in framework of my PhD Student, Ana Teresa Silva (Doctoral Grant SFRH/BD/150649/2020)
The Impact of [C16Pyr][Amp] on the Aggressiveness in Breast and Prostate Cancer Cell Lines
Vieira, A. F.; Marques-Magalhães, A.; Miranda-Gonçalves, V.; Ferraz, R.; Vieira, M.; Prudêncio,
C.; Jerónimo, C.; Silva, R. A.
International Journal of Molecular Sciences, 21: 9584 (2020)
Published in a journal of Q1 in the field of Biochemistry and Molecular Biology. In this work I
was responsible for the synthesis of the Ionic Liquids and the characterization of the
compounds.
Antiproliferative organic salts against cancer: disclosure of an ionic liquid selective against lung and liver cells
Silva, A.T., Cerqueira, M. J., Prudêncio, C., Fernandes, M. H., Costa-Rodrigues J., Teixeira, C. Gomes, P: and Ferraz, R.
ACS Omega, 4, 5682-5689 (2019).
Published in a journal of Q2 in the field of Chemistry, Multidisciplinary. This work was part of the Master thesis of two of my students (Maria João Cerqueira and Ana Teresa Silva). I was responsible for supervising synthesis and the characterization of the compounds but also help designing the experience with cell lines.
Turning a collagenesis-inducing peptide into a potent antibacterial and antibiofilm agent against multidrug-resistant Gram-negative bacteria
Gomes, A. Bessa, L. J., Fernandes, I., Ferraz, R., N. Mateus, N., Gameiro, P. Teixeira, C., and Gomes, P.
Frontiers in Microbiology, 10: 1915 (2019)
Published in a journal of Q1 in the field of Microbiology. In this work I was responsible for the synthesis and characterization of the peptides. This is in framework of my PhD Student, Ana Gomes (Doctoral Grant PD/BD/135073/2017).
